Technically no because the Essential Serum has antioxidants in it but if you're outdoors a lot in summer or year around, it's not a bad idea to use a second, more concentrated form of antioxidant like one of the Vitamin C Serums like the SkinMedica one you mentioned. Here is a list of some of the top anti-aging and wrinkle repair products. Don't forget your sunscreen.  Dr. I