Yes with a couple of adjustments!   You can't use a Retin A gel over a moisturizer but it works with the creams.  Put a light layer of moisturizer on -  WAIT 10 minutes -  and then apply the Retin A/Renova/tretinoin.    It works fine and is much less irritating.  It's also fine to use your Retin A on your crow's feet area.  Don't put it on the eyelid skin itself.  Use your Vitamin C serum in the morning.   Hope this helps!  Dr. I