Tretinoin/Retin A – can I become resistent to it?
Okay, here may be the problem. Are you sure you meant isotretinoin? Tretinoin and isotretinoin are quite different molecules! Check your tube and see. You want tretinoin. I hate to say it but there are companies out there who deliberately put in something cheaper that sounds like something more expensive to confuse consumers.
If it IS tretinoin you have, then it’s not possible to become resistent to it but it IS possible to develop an allergy or irritant reaction to something, usually in the base cream that it’s put into.
Hope this helps, Dr. I